Bionics Program

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Maiko OKADA

Name

Maiko OKADA

Department/Research Field

Molecular cell biology, Molecular endocrinology, Molecular oncology


Research content
The nuclear receptors (NRs) form a super family of a DNA-binding transcription factors which directly bind and respond to various physiologically active substances, such as steroid hormones and fat-soluble vitamin groups, and regulate target gene-expressions. In our research project, (1) we unravel the relationship between NRs and abnormal expression of genomic information in various disease. Based on this, we are aiming (2) to find a novel NR ligand that can control health and disease and (3) a novel disease biomarker to predict the sensitivity of the therapeutic drugs or prognosis. By achieving this, we expected to contribute to drug discovery and highly accurate diagnosis.

Research theme

1. Elucidation of the relationship between NRs and abnormal expression of genomic information. 2. Identification of a novel NR ligand to control health and disease. 3. Identification of a novel biomarker to predict the drug sensitivity or prognosis.

Research keywords
nuclear receptors , expression of genomic information , drug discovery and diagnosis
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